The aim of our Safety Public Assessment Reports is to discuss evidence-based assessments of safety issues for a particular drug or drug class. The Commission on Human Medicines (CHM) advises government ministers and the MHRA on the safety, efficacy and quality of medicines. We continually review the safety of all medicines in the UK and inform healthcare professionals and the public of the latest updates. The Medicines and Healthcare products Regulatory Agency (MHRA) is the government agency responsible for regulating medicines and medical devices in the UK. We have also produced additional materials for patients and healthcare professionals about the best way to minimise the risks of these reactions with topical corticosteroids and what to do if they occur. Information about these reactions will be added to the product information provided to healthcare professionals and patients. however they can be debilitating and long lasting. However, given the number of patients who use topical corticosteroids, we understand that these effects occur very infrequently. We are unable to estimate the frequency of these reactions. There is growing evidence of topical steroid withdrawal reactions if they are used continually for a long time. ![]() ![]() Correct use includes using these medicines to treat certain skin conditions for short periods of time, or with short breaks in treatment over an extended period. When used correctly, topical corticosteroid medicines are safe and effective treatments for skin disorders. The findings and recommendations of the review are summarised in this report. We also sought advice on the review from our experts and from dermatologists and skin charities. We considered whether action should be taken to reduce the risk of these events. We considered side effects reported to us by patients and healthcare professionals, in addition to information published by researchers and other medicines regulators. We conducted a comprehensive review of the evidence available. The MHRA received an enquiry from a patient representative to the Yellow Card scheme about the risk of topical steroid withdrawal reactions, which triggered this assessment. Contact dermatitis – a type of eczema triggered by contact with particular substances, such as soaps and detergentsĮxamples of topical corticosteroid medicines include beclometasone, betamethasone, clobetasol, hydrocortisone, mometasone, and triamcinolone.Psoriasis – a skin condition causes red, flaky, crusty patches of skin covered with silvery scales.Eczema – a condition that causes the skin to become itchy, dry and cracked. ![]() Topical corticosteroids may be used to treat skin disorders such as: These may come in the form of creams, ointments, lotions, mousses, shampoos, gels or tapes. If a corticosteroid is used on the skin, this is known as a topical corticosteroid. The most common type used to treat skin disorders are the corticosteroids. Steroids are natural chemicals produced by the body and also are manufactured to be used as medicines. It is important to follow the advice provided with topical corticosteroid medicines and to contact your doctor if your skin condition doesn’t improve or gets worse, including after you stop using a topical corticosteroid. A particularly severe type of topical steroid withdrawal reaction has been reported with skin redness (or a spectrum of colour changes or change in normal skin tone) and burning worse than the original condition. ![]() However, if used very often or continually for a prolonged time, there have been reports of withdrawal reactions after they are stopped. This review has concluded that when used correctly, topical corticosteroid medicines are safe and effective treatments for skin disorders. The Medicines and Healthcare products Regulatory Agency (MHRA) and the Commission on Human Medicines (CHM) has reviewed the available safety evidence for the risk of topical steroid withdrawal reactions, which have been associated with the use of topical corticosteroids.
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